
Background Information
Breast Cancer has been a rising concern in our society, with over 2.3 million cases worldwide. Breast Cancer tumors increase through processes of transition. These tumors spread rapidly and increase throughout the breast. TBaP, also known as Tetrahydrobenzo(a)pyren-7-ol, is a Polycyclic Aromatic Hydrocarbon. These PAH's can either be found in man made situations or naturally. These situations can be affected due to increased levels of PAH in our society due to the contentious production of PAH, adding more growth of breast cancer. This creates a continuous production of Polycyclic Aromatic Hydrocarbons.
Information Gathered
Tetrahydrobenzo(a)pyren-7-ol
Tetrahydrobenzo(a)pyren-7-ol is a Polycylic Aromatic Hydrocarbon, and is the mutant of Benzo(a)pyrene. Benzo(a)pyrene, a confirmed carcinogen towards skin, bladder, and lung cancer, is a non confirmed carcinogen towards breast cancer. This creates a rising concern for society. Tetrahydrobenzo(a)pyren-7-ol can be found naturally or from man-made situations, including the burning and origin of: gasoline, oil, tobacco, wood, and much more. This can be then lead to contamination of plants and vegetation, increasing the risk of exposure of Tetrahydrobenzo(a)pyren-7-ol.
Breast Cancer
Breast cancer, a rising concern in our society due to the ability to spread throughout the breast through different processes of transition. As Breast Cancer becomes a rising concern since 1987, having a 17% increase in cancer rates to 2023, society will soon be effected more than it has already. Breast cancer cells reproduce more rapidly rather then regular cells, the accumulated mass of breast cancer cells are known as a tumor. With the rising concern, studying the exposure of TBaP against breast cancer allows to study environmental factors increasing the growth.
Procedure + Purpose
The purpose of this experiment is to research how the levels of Tetrahydrobenzo(a)pyren-7-ol (TBaP) increase the growth of breast cancer, showing the affects of Polycyclic Aromatic Hydrocarbons against breast cancer. To proceed with this research, TBaP was placed throughout the agar allowing for the model organism (Physarum Polycephalum) to grow with exposure with TBaP. Looking at 3 different concentrations: .1mg, .2mg, and .3mg; these concentrations are in order of: lower then recommended amount, the recommended amount, and exceeding the recommending daily exposure.
Results
The highest concentration (.3mg) of TBaP was found to have the highest amount of growth. The highest concentration having the highest amount of growth shows that increase in exposure relates to increase in breast cancer tumors. Looking at the .2mg (average concentration) it contained a similar average amount of growth as the control, having an average of .97cm difference in growth. This average is a concern for the recommended daily exposure, as having a similar amount of growth as the control, it shows how fast being exposed to TBaP can increase the growth of breast cancer.